Oxazolidinone compounds and their uses in preparation of antibiotics
AssigneesSichuan Gooddoctor Pharmaceutical Group Co., Ltd, Si Chuan University
InventorsYoufu Luo, Zhenling Wang, Yuquan Wei, Funeng Geng
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Abstract
The invention belongs to the field of medicaments, and particularly relates to oxazolidinone compounds and their uses in the preparation of antibiotics. A technical problem to be solved by the invention is to provide new oxazolidinone compounds having the structure represented by Formula I. The oxazolidinone compounds of the invention, which are new compounds obtained through numerous screening, have significant antibacterial activity against bacteria such as drug-resistant staphylococcus aureus, fecal coliform bacteria, and streptococcus pneumoniae, while exhibiting low toxicity. The invention provides new options for the development and application of antibiotics.
Claims13
An oxazolidinone compound or its pharmaceutically acceptable salt, wherein the compound has a structure represented by Formula I:
- wherein:
- R5 to R8 are each independently H, F, Cl, Br or C1-C8 alkyl;
- R9, R10 and R11 are each independently H,
- and at least one of R9, R10 and R11 is not H;
- R17 is H or C1-C4 alkyl;
- and
- R26 to R29 are each independently H, C1-C4 alkyl, halogen or carboxyl.
Dependencies are inferred from the claim text.