US 8,946,435 B2Granted

Synthesis for thiazolidinedione compounds

AssigneeMetabolic Solutions Development Company, LLC

InventorsSteven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen

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Abstract

The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.

Claims3

Dependent claims

A compound selected from

wherein R3 is hydrogen or an unsubstituted C1-6 alkyl.

Dependencies are inferred from the claim text.

Facts

Application: 14/478,184Filed 5 Sep 2014 · division
Priority: 27 Aug 2010
Published: US 2014/0378687 A125 Dec 2014
Granted: 3 Feb 2015
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 417/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
A61P 3/00
Drugs for disorders of the metabolism
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 3/06
Drugs for disorders of the metabolism: antihyperlipidemics

Family

Application61/377,629Us provisional application · filed 27 Aug 2010
PCT/US2011/046992Parent of this division · filed 9 Aug 2011
US 2014/0378687 A1Pre-grant publication · published 25 Dec 2014
Application13/813,462Parent of this division
US 2013/0211092 A1Published application
US 8,895,748 B2Related patent
US 8,946,435 B2This patent

From the US filing history. Foreign family members aren’t listed.

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