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US 8,946,421 B2Granted
Lipidated imidazoquinoline derivatives
AssigneeGlaxosmithkline Biologicals SA
InventorDavid A. Johnson
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Abstract
The compounds of the subject invention are adjuvant molecules that comprise an imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens.
Claims6
A compound comprising Formula II
- wherein
- R1=H, n-butyl, ethoxymethyl
- n=2-4
- X=O
- Y=O
- W=O
- m=1-2,
- R2=hexadecanoyl, and
- R3=hexadecanoyl.
6 more elements
Dependencies are inferred from the claim text.