Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source
OwnerYvette S. Vaske, Maximillian E. Mahoney +1inventors
InventorsYvette S. Vaske, Maximillian E. Mahoney, Joseph P. Konopelski
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Abstract
Novel methods for the production of enantiomerically pure (EP) β-lactams by decomposition of α-diazo-β-ketoamides using fluorescent light.
Claims11
A method for the production of an enantiomerically pure β-lactam, the method comprising the decomposition of an α-diazo-β-ketoamide derived from an enantiomerically pure α-amino acid wherein the method comprises performing photolysis of the α-diazo-β-ketoamide to produce the corresponding EP β-lactam by means of a light-promoted intramolecular Wolff rearrangement, wherein photolysis is promoted by use of a fluorescent light only, and without the use of a mercury vapour lamp, and wherein no chemical or metal catalyst is used to promote the reaction.
Dependencies are inferred from the claim text.