Compositions and methods for siRNA inhibition of angiogenesis
AssigneeThe Trustees of the University of Pennsylvania
InventorsMichael J. Tolentino, Samuel Jotham Reich
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Abstract
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Claims10
An isolated dsRNA consisting of a 19 to 25 nucleotide sense RNA strand and a 19 to 25 nucleotide antisense RNA strand, wherein the sense and the antisense RNA strands form an RNA duplex, and wherein the antisense RNA strand consists of a nucleotide sequence that hybridizes to SEQ ID NOs:
- 20 or 52.
Dependencies are inferred from the claim text.