Methods for diagnosing lyme disease
AssigneeCornell University
InventorBettina Wagner
Life of this patent
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Abstract
A method for diagnosing Lyme disease status in a mammal is provided. The method entails, in a biological sample obtained or derived from a mammal, determining antibodies to Borrelia burgdorferi (B. burgdorferi) outer surface proteins (Osp) OspA, OspC, and OspF. Based upon determining the OspA, OspC, and OspF antibodies, the mammal can be diagnosed as vaccinated, not vaccinated, infected or not infected with B. burgdorferi. Mammals that have early, intermediate or chronic B. burgdorferi infection can also be identified. The method is particularly suited for use with horses and dogs. Isolated or recombinant B. burgdorferi antigens and compositions that contain them are also provided.
Claims3
A composition comprising a combination of Borrelia burgdorferi (B. burgdorferi) outer surface proteins, wherein the proteins are the only B. burgdorferiproteins in the composition, wherein the proteins comprise the sequences of SEQ ID NO:
- 15, SEQ ID NO:
- 17, and SEQ ID NO:
- 19, wherein the proteins are covalently attached to a solid matrix, wherein the composition is suitable for use in determining vaccination against B. burgdorferi , early B. burgdorferi infection, intermediate B. burgdorferi infection and late B. burgdorferi infection, wherein the early infection is 2 to 6 weeks old, wherein the intermediate infection is from 6 weeks to 5 months old, and wherein the chronic infection is present for more than 5 months.
Dependencies are inferred from the claim text.