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US 8,946,386 B2Granted
Proteins expressed in NK cells
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsKouji Matsushima, Shinichi Hashimoto, Masayuki Tsuchiya, Yuichi Hirata, Kenji Yoshida, Kazuyuki Ojima
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Abstract
Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
Claims19
A polypeptide conjugated to a label, wherein the polypeptide has a sequence comprising the amino acid sequence of SEQ ID NO:2, or the amino acid sequence encoded by SEQ ID NO:
- 3, beginning at nucleotide 88.
A fusion protein comprising:
- a first sequence that is the amino acid sequence of SEQ ID NO:
- 2 or the amino acid sequence encoded by SEQ ID NO:
- 3, beginning at nucleotide 88;
- and
- a second sequence that is an amino acid sequence of another protein or peptide.
2 more elements
Dependencies are inferred from the claim text.