Compositions and uses thereof for the treatment of wounds
AssigneesPhylogica Limited, The McComb Foundation, Inc.
InventorsMark Fear, Paul Watt, Richard Hopkins, Nadia Milech
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Abstract
The present invention provides a topical composition comprising (i) an amount of an AP-1 signaling inhibitor sufficient to reduce, delay or prevent apoptosis and/or necrosis induced by dermal wounding and/or to induce and/or enhance proliferation of a cell; and (ii) a suitable carrier or excipient e.g., a topical carrier or excipient or other carrier or excipient for dermal application. For example, the AP-1 signaling inhibitor is a peptide analog comprising the sequence set forth in SEQ ID NO: 104. The present invention also provides a method of treating a dermal wound comprising topically administering said topical composition to a subject suffering from a dermal wound.
Claims21
A topical composition comprising (i) an amount of a peptide analog consisting of an amino acid sequence set forth by SEQ ID NO:
- 104 wherein all amino acids other than glycine are D-amino acids;
- and (ii) a suitable carrier or excipient.
Dependencies are inferred from the claim text.