Selective sigma-1 receptor ligands
AssigneeWisconsin Alumni Research Foundation
InventorsArnold E. Ruoho, Abdol R. Hajipour, Uyen B. Chu, Dominique A. Fontanilla
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Abstract
The invention provides compounds of the formulas described herein and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.
Claims19
A compound of formula XI:
- wherein
- R1 is substituted phenyl, or substituted benzyl;
- and
- when R1 is phenyl, the phenyl of R1 is substituted with one to five halo, amino, azido, alkyl, or trifluoromethyl groups, or a combination thereof;
- when R1 is benzyl, the benzyl of R1 is substituted with:
- one to five amino, azido, or alkyl groups, or a combination thereof;
- one to four azido groups and one to four halo, amino, alkyl, or trifluoromethyl groups, or a combination thereof;
- one to four alkyl groups and one to four halo, amino, azido, or trifluoromethyl groups, or a combination thereof;
- two to four amino groups and one to three halo, azido, alkyl, or trifluoromethyl groups, or a combination thereof;
- three to five halo groups and one to two amino, azido, alkyl, or trifluoromethyl groups, or a combination thereof;
- or
- three to five trifluoromethyl groups and one to two halo, amino, azido, or alkyl groups, or a combination thereof;
- or a salt thereof.
Dependencies are inferred from the claim text.