Histone hyperacetylating agents for promoting wound healing and preventing scar formation
AssigneeSunny Pharmtech Inc.
InventorYih-Lin Chung
Life of this patent
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Abstract
A method for promoting wound healing and preventing scar formation in a variety of wounds in skin, mucosa, and cornea. The method comprises administering a therapeutically effective amount of a histone deacetylase inhibitor or a hyperacetylating agent. The histone deacetylase inhibitor or hyperacetylating agent is capable of stimulating multiple cytokines/growth factors in the early phase of wound healing, and suppressing fibrogenic cytokines/growth factors in the late phase of tissue remodeling in the wound site, and is useful in promoting epithelial cell re-growth and reducing excessive collagen accumulation, which results in rapid wound closure with reduced scaring.
Claims15
A method for promoting a wound healing process in skin, mucosa, or cornea, comprising applying to a wound in a subject in the inflammation phase or the tissue forming phase of the wound healing process a pharmaceutical composition including a therapeutically effective amount of a histone deacetylase inhibitor or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the histone deacetylase inhibitor is selected from the group consisting of trichostatin A, trichostatin C, sodium butyrate, isovalerate, valerate, 4-phenylbutyrate, sodium phenylbutyrate, propionate, butyramide, isobutyramide, phenylacetate, 3-bromopropionate, valproic acid, valproate, and tributyrin, and wherein the wound is selected from the group consisting of ulcer resulting from a chemical injury, phototoxic reactions, ulcer from an infectious process, desquamation resulting from drug eruption, oral aphthae, contact and irritant stomatitis, and dental erosion.
Dependencies are inferred from the claim text.