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US 8,946,293 B2Granted
Methods of intravenous administration of glyburide and other drugs
AssigneeRemedy Pharmaceuticals, Inc.
InventorSven Martin Jacobson
Life of this patent
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AssigneeRemedy Pharmaceuticals, Inc.
InventorSven Martin Jacobson
Estimating the term…
Methods of administering glyburide, or other drug, are disclosed. The novel methods disclosed herein include intravenous methods of administering glyburide, or other drug, over periods of more than an hour, preferably over periods of about 72 hours. The novel methods include administering a bolus of glyburide, or other drug, followed by a first continuous infusion administration of glyburide, or other drug; and optionally a second or further bolus administration of glyburide, or other drug, and/or a second or further continuous infusion administration of glyburide, or other drug. These methods are effective to rapidly achieve a desired level of glyburide, or other drug, and to provide a substantially steady level of glyburide, or other drug, over a desired period of time. The methods disclosed herein may be useful for treating a subject in need of treatment for, e.g., acute stroke (ischemic and hemorrhagic), traumatic brain injury (TBI), spinal cord injury (SCI), myocardial infarction (MI), shock (including hemorrhagic shock), organ ischemia, and ventricular arrhythmias. These methods provide for the rapid achievement and maintenance of therapeutic glyburide, or other drug, plasma levels over an extended period of time, and further avoid excessive levels of drug and so avoid possible drug side-effects.
A method of treating acute stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, ventricular arrhythmias, ischemic injury, hypoxia/ischemia, or other injuries, conditions, and disorders, in a subject in need of treatment, comprising administration of a first bolus and a second bolus of glyburide followed by a continuous infusion of glyburide to a subject in need of treatment, said administration comprising:
A method of treating acute stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, Of ventricular arrhythmias, ischemic injury, hypoxia/ischemia, or other injuries, conditions, and disorders, in a subject in need of treatment, comprising administration of a bolus of glyburide followed by a first and a second continuous infusion of glyburide to a subject in need of treatment, said administration comprising:
A method of treating acute stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, ventricular arrhythmias, ischemic injury, hypoxia/ischemia, or other injuries, conditions, and disorders, in a subject in need of treatment, comprising administration of a bolus of glyburide followed by a first, a second, and a third continuous infusion of glyburide to a subject in need of treatment, said administration comprising:
Dependencies are inferred from the claim text.