Uses of hydroxyl polymethoxylflavones (HPMFs) and derivatives thereof

A method of treating or preventing a disease selected from the group consisting of obesity, fatty liver, metabolic syndrome, insulin resistance syndrome, cardiovascular disease, hypertension and hyperlipidemia, comprising

• step A:
• taking a predetermined amount of an extract from a peel of citrus fruit;
• step B:
• dissolving the extract with alcohols and then adding hydrochloric acid to obtain a first mixture;
• step C:
• incubating the first mixture with heating circumfluence, and then removing the alcohols, so as to obtain a second mixture;
• step D:
• extracting the second mixture by water and an organic solvent;
• step E:
• collecting an organic phase obtained with the organic solvent, and then purifying, so as to obtain a hydroxyl polymethoxylflavones (HPMFs) compound;
• and
• step F:
• administering an effective amount of a composition to a subject, the composition including the hydroxyl polymethoxylflavones compound, a pharmaceutically acceptable salt thereof, or a mixture thereof.