Organic amine salts of aminobenzoic acid derivatives and method for producing same
AssigneeNissan Chemical Industries, Ltd.
InventorsShunsuke Iwamoto, Satoshi Nakano, Mariko Ishida, Masao Yamamoto, Kazuya Takeuchi
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Abstract
A novel organic amine salt or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid having useful properties as a drug is provided. A novel organic amine or salt with quaternary ammonium ion of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid, a method for producing the organic amine salt or the salt with quaternary ammonium ion and a platelet increasing agent.
Claims18
A salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene} hydrazino)carbonothioyl]amino}benzoic acid, which is selected from the group consisting of:
- an ethanolamine salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]aminol}benzoic acid;
- a tromethamine salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]aminol}benzoic acid;
- and
- a choline salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid.
An ethanolamine salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid.
A tromethamine salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]-amino}benzoic acid.
A choline salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid.
A method for producing an organic amine salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid,
- said method comprising reacting 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3thienyl]ethylidene }hydrazino)carbonothioyl]amino}benzoic acid with an organic amine, in a solvent,
- wherein said organic amine is ethanolamine and said solvent is acetonitrile.
A method for producing an organic amine salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid,
- said method comprising reacting 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid with an organic amine, in a solvent,
- wherein said organic amine is tromethamine and said solvent is tetrahydrofuran, and
- after formation of said organic amine salt, crystallizing said organic amine salt by adding acetonitrile to said tetrahydrofuran.
A method for producing an organic amine salt of 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidenel}hydrazino)carbonothioyl]amino}benzoic acid,
- said method comprising reacting 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid with an organic amine, in a solvent,
- wherein said organic amine is tromethamine and said solvent is a mixture of acetone and water, and
- after formation of said organic amine salt, crystallizing said organic amine salt by replacing said mixture of acetone and water with 1-propanol.
A method for producing an organic amine salt of 3-{[((2E)-2-{1-[5(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid,
- said method comprising reacting 3-{[((2E)-2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid with an organic amine, in a solvent,
- wherein said organic amine is choline and said solvent is acetonitrile.
Dependencies are inferred from the claim text.