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US 8,946,273 B2Granted
S-Triazolyl alpha-mercapto acetanilides as inhibitors of HIV reverse transcriptase
AssigneeArdea Biosciences, Inc.
InventorsJean-Luc Girardet, Yung-Hyo Koh, Martha A. De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Woo-Hong Kim
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Abstract
A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
Claims10
A compound of Formula A′:
- wherein:
- R1 is C1-3 alkyl, CF3, CHF2, CH2F, Cl, Br, NH2, or hydrogen;
- R2 is an aryl or heteroaryl moiety which can be further substituted with alkyl, cycloalkyl, aryl or heteroaryl moieties;
- Q is C3-5 cycloalkyl;
- W is S, O, or an optionally substituted amine;
- R3 is C1-3 alkyl, CF3, CHF2, CH2F, Cl or Br;
- and
- R4 is COR′ or S(O)2R′, wherein R′ is NH2 or NH(alkyl).
5 more elements
Dependencies are inferred from the claim text.