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US 8,946,271 B2Granted
Water soluble furoxan derivatives having antitumor activity
AssigneesHumanitas Mirasole S.P.A., Istituto Oncologico Veneto IRCCS
InventorsAntonella Viola, Enzo Bronte, Marco Crosetti, Loretta Lazzarato, Roberta Fruttero, Alberto Gasco
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Abstract
Water soluble compounds having a furoxan structure which are capable of inhibiting metabolic pathways involved in the development of the tumours are provided. The use of such compounds as a medicament in the therapy of the tumours and as an adjuvant in the immunotherapy protocols against neoplasms is also described.
Claims8
A compound having a formula selected from the group consisting of:
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.