Compositions and methods for modulating circadian synchronization
AssigneeMax-Planck-Gesellchaft zur Forderung der Wissenschaften e.V.
InventorsGregor Eichele, Henrik Oster, Silke Kiessling
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Abstract
The present invention relates to a modulator of glucocorticoid biosynthesis, degradation and/or receptor activation for use in preventing or treating symptoms and/or diseases associated with jet lag. The compositions of the invention may be used as a lead compound for developing a drug for preventing or treating symptoms and/or diseases associated with jet lag. The invention relates to the discovery that administration of the modulator(s) to a subject results in a directional change of the time point of maximum amounts of glucocorticoids in the subject as compared to the time point of maximum amounts of glucocorticoids in a subject not treated with the modulator(s).
Claims7
A method of treating symptoms and/or diseases associated with jet lag comprising administering to a subject in need thereof a pharmaceutically effective amount of a modulator of at least one of glucocorticoid biosynthesis or degradation, wherein the modulator is metyrapone.
Dependencies are inferred from the claim text.