Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors
AssigneeHigh Point Pharmaceuticals, LLC
InventorsAdnan M. M. Mjalli, David Robert Jones, Devi Reddy Gohimukkula, Guoxiang Huang, Jeff Jiqun Zhu, Mohan Rao, Robert Carl Andrews, Tan Ren
Life of this patent
Estimating the term…
Abstract
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
Claims3
A method of inhibiting in a subject the interaction of beta-secretase 1 with amyloid precursor protein comprising administering to the subject a compound, wherein the compound is Isoquinoline-3-carboxylic acid [7-(1H-imidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-amide or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.