3,4-diarylpyrazoles as protein kinase inhibitors

A compound of formula (I):

• wherein:
• m is an integer from 0 to 2;
• R1 is hydrogen, trichloromethyl, trifluoromethyl, halogen, cyano, OH, OR8, NR9R10, NR21COR22, COOH, COOR11, CONR12R13, or a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C2-C8) alkenyl or (C2-C8) alkynyl, (C3-C8) cycloalkyl, (C3-C8) cycloalkenyl, heterocyclyl, aryl and heteroaryl, wherein:
• R8 and R11 are each independently a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R9, R10, R12 and R13 the same or different, are each independently hydrogen or a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, heterocyclyl, aryl and heteroaryl, or taken together with the nitrogen atom to which they are bonded either R9 and R10 as well as R12 and R13 may form an optionally substituted heterocyclyl or heteroaryl, optionally containing one additional heteroatom or heteroatomic group selected from S, O, N or NH;
• R21 and R22 the same or different, are each independently hydrogen or a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, heterocyclyl, aryl and heteroaryl, or taken together with the atoms to which they are bonded R21 and R22 may form an optionally substituted heterocyclyl, optionally containing one additional heteroatom or heteroatomic group selected from S, O, N or NH;
• X is —CH or N;
• R2 is hydrogen, halogen, NR14R15, SR23 or SO2R23, wherein:
• R14 and R15 are independently hydrogen or a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, heterocyclyl, and heteroaryl;
• or taken together with the nitrogen atom to which they are bonded R14 and R15 may form an optionally substituted 3 to 8 membered heterocyclyl or heteroaryl, optionally containing one additional heteroatom or heteroatomic group selected from S, O, N or NH;
• or R14 is hydrogen and R15 is COR16,
• wherein:
• R16 is OR17, NR18R19 or a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C2-C8) alkenyl or (C2-C8) alkynyl, (C3-C8) cycloalkyl, (C3-C8) cycloalkenyl, heterocyclyl, aryl and heteroaryl, wherein:
• R17 is a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R18 and R19 are each independently a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, heterocyclyl, aryl and heteroaryl, or taken together with the nitrogen atom to which they are bonded R18 and R19 may form an optionally substituted 3 to 8 membered heterocyclyl or heteroaryl, optionally containing one additional heteroatom or heteroatomic group selected from S, O, N or NH;
• R23 is a group optionally substituted selected from straight or branched (C1-C8) alkyl, (C3-C8) cycloalkyl, heterocyclyl, aryl and heteroaryl,
• R3, R4, R5 and R6 are each independently hydrogen, halogen, trifluoromethyl, trichloromethyl, cyano, OR20 or a group optionally substituted selected from straight or branched (C1-C8) alkyl, and (C3-C8) cycloalkyl, wherein:
• R20 is a group optionally substituted selected from straight or branched (C1-C8) alkyl and (C3-C8) cycloalkyl;
• A is —CON(Y), —CON(Y)O—, —CON(Y)N(Y)—, —CON(Y)SO2—, —SO2N(Y)—, —N(Y)CO—, —N(Y)SO2—, —N(Y)CON(Y)—, —N(Y)CSN(Y)—, —N(Y)COO—, C(R′R″)CON(Y)—, —C(R′ R″)N(Y)CO, or —C(R′R″)N(Y)CON(Y)—,
• wherein:
• Y is hydrogen or an optionally substituted straight or branched (C1-C3) alkyl;
• and R′ and R″ are independently hydrogen or an optionally further substituted straight or branched (C1-C6) alkyl, or taken together with the carbon atom to which they are bonded R′ and R″ may form an optionally substituted (C3-C8) cycloalkyl;
• R7 is hydrogen or an optionally substituted group selected from straight or branched (C1-C8) alkyl, (C2-C8) alkenyl, or (C3-C8) cycloalkyl, (C2-C8) alkynyl, (C3-C8) cycloalkenyl, heterocyclyl, aryl and heteroaryl;
• or a pharmaceutically acceptable salt thereof.