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US 8,946,243 B2Granted
Compounds and methods for the treatment of viral infection
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, Katholieke Universiteit Leuven
InventorsLeonid Margolis, Jan Balzarini, Christopher McGuigan, Andrea Lisco, Christophe Vanpouille, Marco Derudas
Life of this patent
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Abstract
The invention relates to compounds and methods for treating or preventing a viral infection, by administering a monophosphorylated prodrug of acyclovir or monophosphorylated derivative of an acyclovir prodrug to a subject suffering from or susceptible (to a viral infection, such as HIV infection.
Claims12
A compound represented by the formula (Formula I):
- wherein:
- Ar is an aryl group having 6 to 30 carbon atoms or a heteroaryl group having 6 to 30 atoms, wherein the aryl or heteroaryl group may be substituted with 1-3 substituents;
- Q is O, S, or CR4R5, wherein R4 and R5 are independently selected from H and C1-C6 alkyl;
- X is H, or CH2OH;
- R1 and R2 are independently selected from H, or the group consisting of optionally substituted C1-C20 alkyl, C2-C20 alkenyl, C1-20 alkoxy, C2-C20 alkynyl, or C3-C20 cycloalkyl;
- or
- R1 and R2 are fused to form a contiguous carbocyclic or heterocyclic ring consisting of 3-20 carbons in total;
- and
- each of R and R3 is independently selected from the group consisting of H, and optionally substituted C1-C20 alkyl, C3-C20 cycloalkyl, C2-C20 alkenyl, C1-20 alkoxy, or C6-C30 alkynyl;
- or
- R and R1 are taken together with the nitrogen and carbon atoms to which they are respectively attached to form a ring consisting of 4-6 C or N atoms;
- pharmaceutically acceptable salts, amine prodrugs, ester prodrugs, carbamate and carbonate prodrugs, ureide prodrugs, and phosphate prodrugs thereof;
- with the proviso that if Ar is phenyl, R is H, R1 and R2 differ and consist of a methyl and an H, X is H, R3 is H or methyl, then Q cannot be O.
10 more elements
Dependencies are inferred from the claim text.