Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
AssigneeDuquesne University of the Holy Spirit
InventorAleem Gangjee
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Abstract
The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of formula III, and 5,6-saturated and unsaturated and pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
Claims2
A compound of Formula III:
- and 5,6-saturated and unsaturated
- with respect to the five membered ring;
- R1 is CH3 when R2 is a methoxyphenyl group, or wherein R1 is methoxyphenyl group when R2 is CH3;
- R3 is CH3;
- R5 is CH3;
- R6 is a hydrogen (H);
- X is an oxygen (O);
- and
- Y is a nitrogen (N).
A pharmaceutical composition comprising a compound of Formula III and pharmaceutically acceptable salts thereof:
- and 5,6-saturated and unsaturated
- with respect to the five membered ring;
- R1 is CH3 when R2 is a methoxyphenyl group, or wherein R1 is methoxyphenyl group when R2 is CH3;
- R3 is CH3:
- R5 is CH3:,
- R6 is a hydrogen (H);
- X is an oxygen (O);
- and
- Y is a nitrogen (N).
Dependencies are inferred from the claim text.