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US 8,946,229 B2Granted
Formulations
AssigneeUcb, S.A.
InventorsDomenico Fanara, Monique Berwaer, Anthony Guichaux, Michel Deleers
Life of this patent
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Abstract
The present invention relates to pharmaceutical compositions for oral administration of active compounds.
Claims15
A chewable tablet pharmaceutical composition consisting of two layers,
- a first layer comprising a first formulation, which contains an active compound selected from 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids and their amides having the general formula I
- wherein
- R1 is a —COOH group or a —CONH2 group, and
- X1 and X2, taken separately, each represent a hydrogen atom, a halogen atom, a straight-chain or branched C1-C4 alkoxy group or a trifluoromethyl group as well as their pharmaceutically acceptable salts, geometrical isomers, enantiomers, diastereomers and mixtures thereof, wherein the first layer does not contain polyols having a molecular weight of less than 300 in a molar ratio between the polyol and active compound of formula I above 10;
- and
- a second layer comprising a second formulation, which contains one or more solid polyol(s) with a molecular weight of less than 3000, wherein the second layer is free of any drug,
- wherein the tablet is chewable, and wherein at least one of the formulations further contains an alkalinizing agent.
4 more elements
Dependencies are inferred from the claim text.