Piperidine/piperazine derivatives

A compound of formula

• including any stereochemically isomeric form thereof, wherein
• A represents N;
• X represents —O—C(═O)—;
• —C(═O)—C(═O)—;
• —NRx—C(═O)—;
• —Z—C(═O)—;
• —Z—NRx—C(═O)—;
• —C(═O)—Z—;
• —NRx—C(═O)—Z—;
• —C(═S)—;
• —NRx—C(═S)—;
• —Z—C(═S)—;
• —Z—NRx—C(═S)—;
• —C(═S)—Z—;
• or —NRx—C(═S)—Z—;
• Z represents a bivalent radical selected from C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl;
• wherein each of said C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl may optionally be substituted with hydroxyl or amino;
• and wherein two hydrogen atoms attached to the same carbon atom in C1-6alkanediyl may optionally be replaced by C1-6alkanediyl;
• Rx represents hydrogen or C1-4alkyl;
• Y represents —C(═O)—NRx— or —NRx—C(═O)—;
• R1 represents adamantanyl, C3-6cycloalkyl;
• aryl1 or Het1;
• R2 represents C3-6cycloalkyl, phenyl, naphthalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms is substituted with two, three, four or five substituents, each substituent independently selected from the group consisting of hydroxyl;
• carboxyl;
• halo;
• C1-6alkyl optionally substituted with hydroxy;
• polyhaloC1-6alkyl;
• C1-6alkyloxy optionally substituted with C1-4alkyloxy;
• C1-6alkylthio;
• polyhalo-C1-6alkyloxy;
• C1-6alkyloxycarbonyl wherein C1-6alkyl may optionally be substituted with aryl;
• cyano;
• C1-6alkylcarbonyl;
• nitro;
• amino;
• mono- or di(C1-4alkyl)amino;
• C1-4alkylcarbonylamino;
• —S(═O)p—C1-4alkyl;
• R4R3N—C(═O)—;
• R4R3N—C1-6alkyl;
• C3-6cycloalkyl;
• C3-6cycloalkylC1-4alkyl;
• C3-6cycloalkyl-C(═O)—;
• aryl;
• aryloxy;
• arylC1-4alkyl;
• aryl-C(═O)—C1-4alkyl;
• aryl-C(═O)—;
• Het;
• HetC1-4alkyl;
• Het-C(═O)—C1-4alkyl;
• Het-C(═O)—;
• and Het-O—;
• R3 represents hydrogen;
• C1-4alkyl optionally substituted with hydroxyl or C1-4alkyloxy;
• R6R5N—C1-4alkyl;
• C1-4alkyloxy;
• Het;
• Het-C1-4alkyl;
• aryl;
• or R6R5N—C(═O)—C1-4alkyl;
• R4 represents hydrogen or C1-4alkyl;
• R5 represents hydrogen;
• C1-4alkyl;
• or C1-4alkylcarbonyl;
• R6 represents hydrogen or C1-4alkyl;
• or
• R5 and R6 may be taken together with the nitrogen to which they are attached to form a saturated monocyclic 5, 6 or 7-membered heterocycle which may further contain one or more heteroatoms each independently selected from the group consisting of O, S, S(═O)p and N;
• and which heterocycle may optionally be substituted with C1-4alkyl;
• R7 represents hydrogen;
• halo;
• C1-4alkyl;
• or C1-4alkyl substituted with hydroxyl;
• aryl represents phenyl or phenyl substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl;
• carboxyl;
• halo;
• C1-6alkyl optionally substituted with C1-4alkyloxy, amino or mono- or di(C1-4alkyl)amino;
• polyhaloC1-6alkyl;
• C1-6alkyloxy optionally substituted with C1-4alkyloxy;
• C1-6alkylthio;
• polyhaloC1-6alkyloxy;
• C1-6alkyloxycarbonyl;
• cyano;
• aminocarbonyl;
• mono- or di(C1-4alkyl)aminocarbonyl;
• C1-6alkylcarbonyl;
• nitro;
• amino;
• mono- or di(C1-4alkyl)amino;
• and —S(═O)p—C1-4alkyl;
• aryl1 represents phenyl, or fluorenyl;
• each of said phenyl, or fluorenyl optionally substituted with one or two substituents, each substituent independently being selected from the group consisting of oxo;
• carboxyl;
• halo;
• C1-6alkyl optionally substituted with carboxyl or C1-4alkyloxycarbonyl;
• C1-6alkyloxy;
• C1-6alkyloxy-carbonyl;
• amino;
• aryl;
• and Het;
• Het represents a monocyclic non-aromatic or aromatic heterocycle containing at least one heteroatom each independently selected from the group consisting of O, S, S(═O)p and N;
• or a bicyclic or tricyclic non-aromatic or aromatic heterocycle containing at least one heteroatom each independently selected from the group consisting of O, S, S(═O)p and N;
• said monocyclic heterocycle or said bi- or tricyclic heterocycle optionally being substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl;
• oxo;
• carboxyl;
• halo;
• C1-6alkyl optionally substituted with C1-4alkyloxy, amino or mono- or di(C1-4alkyl)amino;
• polyhaloC1-6alkyl;
• C1-6alkyloxy optionally substituted with C1-4alkyloxy;
• C1-6alkylthio;
• polyhaloC1-6alkyloxy;
• C1-6alkyloxycarbonyl;
• cyano;
• aminocarbonyl;
• mono- or di(C1-4alkyl)aminocarbonyl;
• C1-6alkylcarbonyl;
• nitro;
• amino;
• mono- or di(C1-4alkyl)amino;
• and —S(═O)p—C1-4alkyl;
• Het1 represents a monocyclic non-aromatic or aromatic heterocycle containing at least one heteroatom each independently selected from the group consisting of S and N;
• said monocyclic heterocycle optionally being substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl;
• oxo;
• carboxyl;
• halo;
• C1-6alkyl optionally substituted with aryl-C(═O)—;
• hydroxyC1-6alkyl optionally substituted with aryl or aryl-C(═O)—;
• polyhaloC1-6alkyl;
• C1-6alkyloxy optionally substituted with C1-4alkyloxy;
• C1-6alkylthio;
• polyhaloC1-6alkyloxy;
• C1-6alkyloxy-carbonyl wherein C1-6alkyl may optionally be substituted with aryl;
• cyano;
• aminocarbonyl;
• mono- or di(C1-4alkyl)aminocarbonyl;
• C1-6alkylcarbonyl;
• nitro;
• amino;
• mono- or di(C1-6alkyl)amino;
• R4R3N—C1-6alkyl C3-6cycloalkyl-NRx—;
• aryl-NRx—;
• Het-NRx—;
• C3-6cycloalkylC1-4alkyl-NRx—;
• arylC1-4alkyl-NRx—;
• HetC1-4alkyl-NRx—;
• —S(═O)p—C1-4alkyl;
• C3-6cycloalkyl;
• C3-6cycloalkylC1-4alkyl;
• C3-6cycloalkyl-C(═O)—;
• aryl;
• aryloxy;
• arylC1-4alkyl;
• aryl-C(═O)—C1-4alkyl;
• aryl-C(═O)—;
• Het;
• HetC1-4alkyl;
• Het-C(═O)—C1-4alkyl;
• Het-C(═O)—;
• and Het-O—;
• p represents 1 or 2;
• a N-oxide thereof, or a pharmaceutically acceptable salt thereof.