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US 8,946,226 B2Granted
Use of CDK inhibitor for the treatment of glioma
AssigneeNerviano Medical Sciences S.R.L.
InventorsMarina Ciomei, Francesco Fiorentini, Enrico Pesenti
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Abstract
The invention provides a low molecular weight ATP-competitive CDK inhibitor able to cross the blood brain barrier for use in the treatment of malignant glioma and, in particular, of glioblastoma. The compound can be administered together with one or more agents selected from the group consisting of cytotoxic or cytostatic agents and ionizing radiation.
Claims2
A method for treating a malignant glioma, the method comprising administration of a compound of formula (I)
- or a pharmaceutically acceptable salt thereof in combination with one or more antineoplastic agents, wherein the agent is temozolomide.
Dependencies are inferred from the claim text.