Derivatives of 2H pyridazin-3-ones, their preparation and their use as SCD-1 inhibitors

Compounds of general formula (I),

• wherein
• R1 represents one or more groups selected from the group consisting of trifluoromethyl, halogen, C1-C4 straight and branched alkyl, nitro, trifluoromethoxy, acetyl,
• when n=m=1,
• W represents CH then Y is oxygen or —CH2N(CH3)— or —NHCH2—,
• or W represents nitrogen then Y represents C═O,
• when n=m=0, W represents CH, then Y is O or —OCH2—,
• when n=1 and m=0, W represents CH, then Y is —OCH2—,
• U represents:
• either —(C═O)CH2O— and can be branched at position (4) or (5) of pyridazinone and R2 represents hydrogen,
• or —(C═O)CHR4NR5— in which R4═R3═H or, independently of each other, can be equal to H or OMe, and if U is branched at position (4) of pyridazinone then R2 is at position (5) and represents H or OMe, and if U is branched at position (5) of pyridazinone then R2 represents H,
• or —(C═O)NH— and can be branched at position (4) or (5) or (6) of pyridazinone and R2 represents H,
• or —(C═O)(C═O)NH—, —(C═O)CH═CH—, —(C═O)CH2CH2—, and can be branched at position (4) of pyridazinone, then R2 represents H,
• R3 represents:
• a hydrogen, or
• a C1-C6 straight or branched alkyl radical, or a C1-C3 alkyl radical substituted by groups such as:
• trifluoromethyl, phenyl, or C3 alkynyl,
• and the addition salts with pharmaceutically acceptable bases and acids, and the different isomers, and their mixtures in any proportion.