CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments

A compound according to formula (I),

• wherein R1 is a group selected from among —H, -halogen, —CN, —O—C1-C4-alkyl, —C1-C4-alkyl, —CH═CH2, —C≡H, —CF3, —OCF3, —OCF2H, —C5-C10-heteroaryl, and —OCFH2, and wherein R7 is a group selected from among —H, -halogen, —CN, —O—C1-C4-alkyl, —C1-C4-alkyl, —CH═CH2, —C≡CH, —CF3, —OCF3, —OCF2H, and —OCFH2;
• or wherein R7 and R1 on two neighbouring ring atoms together form a —C3-C6-alkenylene group, such that an annellated aromatic ring is formed, in which one or two or three carbon centers may optionally be replaced by 1 or 2 or 3 hetero atoms selected from N, O, and S,
• wherein the resulting annelated ring being optionally substituted by one or more groups selected from among —OH, —NH2, —C1-C3-alkyl, —O—C1-C6-alkyl, —CN, —CF3, —OCF3, and halogen;
• wherein R4 is a group selected from among -hydrogen, —C1-C3-alkyl, —CF3, —OCF3, —OCF2H, -halogen, —CN, —O—C1-C4-alkyl, —CH═CH2, —C≡H, and —OCFH2;
• wherein A is C or N;
• wherein R14 is a group selected from among -hydrogen, and —C1-C3-alkyl;
• wherein R2 is selected from among —H, -halogen, —CN, —O—C1-C4-alkyl, —C1-C4-alkyl, -cyclopropyl, —CH═CH2, —C≡H, —CF3, —OCF3, —OCF2H, and —OCFH2;
• wherein R3 is selected from among —H, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, —OCH3, —CF3, and —CN;
• wherein n is 1, 2 or 3;
• wherein G and E are N;
• wherein R5 is a group of the structure -L1-R13,
• wherein L1 is selected from among —NH— and —N(C1-C4-alkyl)-,
• wherein R13 is —C3-C8-heterocyclyl,
• wherein R13 is optionally substituted by one or more groups selected from among halogen, —CF3, —OCF3, —CN, —OH, —O—C1-C4-alkyl, —C1-C6-alkyl;
• wherein R6 is selected from among —H, —C1-C4-alkyl, —OH, —O—C1-C4-alkyl, -halogen, —CN, —CF3, and —OCF3;
• as well as in form of their acid addition salts with pharmacologically acceptable acids.