Pharmaceutical compounds

A pharmaceutical composition comprised of a fused pyrimidine compound of formula (I):

• wherein
• A represents a thiophene or furan ring;
• n is 1 or 2;
• R1 is a group of formula:
• wherein
• m is 0 or 1;
• R30 is H or C1-C6 alkyl;
• R4 and R5 form, together with the N atom to which they are attached, a 5- or 6-membered saturated N-containing heterocyclic group which includes 0 or 1 additional heteroatoms selected from N, S and O, which may be fused to a benzene ring and which is unsubstituted or substituted;
• or one of R4 and R5 is alkyl and the other is a 5- or 6-membered saturated N-containing heterocyclic group as defined above or an alkyl group which is substituted by a 5- or 6-membered saturated N-containing heterocyclic group as defined above;
• R2 is selected from:
• wherein R6 and R7 form, together with the nitrogen atom to which they are attached, a morpholine, thiomorpholine, piperidine, piperazine, oxazepane or thiazepane group which is unsubstituted or substituted;
• and
• wherein Y is a C2-C4 alkylene chain which contains, between constituent carbon atoms of the chain and/or at one or both ends of the chain, 1 or 2 heteroatoms selected from O, N and S, and which is unsubstituted or substituted;
• and
• R3 is an indazole group which is unsubstituted or substituted;
• or a pharmaceutically acceptable salt thereof, and
• a carrier, diluent or excipient selected from calcium carbonate, sodium carbonate, calcium phosphate, sodium phosphate, cellulose, lactose, sodium carboxymethylcellulose, talc, calcium stearate, glyceryl monostearate, methylcellulose, hydroxypropylmethyl-cellulose, polyvinylpyrrolidone, gum tragacanth, gum acacia, glyceryl distearate, polysorbate, lauryl sulphate and magnesium stearate.