Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use

A compound of formula (I)

• in which
• A represents CH2, CD2 or CH(CH3),
• R1 represents (C4-C6)-alkyl, (C3-C7)-cycloalkyl, pyridyl or phenyl,
• where (C4-C6)-alkyl may be substituted up to six times by fluorine,
• where (C3-C7)-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C1-C4)-alkyl,
• where pyridyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C1-C4)-alkyl,
• and
• where phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, (C3-C6)-cycloalkyl, (C1-C4) -alkoxy, difluoromethoxy and trifluoromethoxy or at two adjacent carbon atoms of the phenyl group by a difluoromethylenedioxy bridge,
• R2 represents hydrogen, (C1-C4)-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl,
• R3 represents a group of the formula
• where
• * represents the point of attachment to the carbonyl group,
• L1A represents a bond or (C1-C4)-alkanediyl,
• where (C1-C4)-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, hydroxy and (C1-C4)-alkoxy,
• L1B represents a bond or (C1-C4)-alkanediyl,
• L1C represents a bond or (C1-C4)-alkanediyl,
• where (C1-C4)-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, hydroxy and (C1-C4)-alkoxy,
• R7 represents hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C7)-cycloalkyl, (C1-C4)-alkoxycarbonyl, 5- or 6-membered heteroaryl or phenyl,
• where (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkylthio, (C1-C4)-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
• where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen substituents,
• where (C3-C7)-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylsulphonyl,
• and
• where phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, trifluoromethyl, (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylsulphonyl,
• R8 represents hydrogen or (C1-C4)-alkyl,
• where (C1-C4)-alkyl may be substituted by hydroxy,
• or
• R7 and R8 together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
• where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C1-C4)-alkyl,
• R9 represents hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C7)-cycloalkyl, (C1-C4)-alkoxycarbonyl, 5- or 6-membered heteroaryl or phenyl,
• where (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkylthio, (C1-C4)-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
• where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen substituents,
• where (C3-C7)-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl and (C1-C4)-alkoxy,
• and
• where phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, trifluoromethyl, (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylsulphonyl,
• R10 represents hydrogen or (C1-C4)-alkyl,
• where (C1-C4)-alkyl may be substituted by hydroxy,
• or
• R9 and R10 together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
• where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C1-C4)-alkyl,
• with the proviso that the radicals R7 and R9 do not both represent phenyl,
• or
• R7 and R9 together with the carbon atoms to which they are attached and with the group L1B form a 5- to 10-membered carbocycle,
• with the proviso that not more than one of the radical pairs R7 and R8, R9 and R10 and R7 and R9, respectively, forms a carbo- or heterocycle,
• L2 represents straight-chain (C2-C4)-alkanediyl,
• L3 represents straight-chain (C2-C4)-alkanediyl,
• R4 represents hydrogen,
• R5 represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, (C2-C4)-alkynyl, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl,
• R6 represents hydrogen, cyano or halogen,
• or a salt thereof.