Non-aqueous pharmaceutical composition
AssigneeArchimedes Development Limited
InventorsJonathan Castile, Alan Smith, Yu-Hui Cheng, Peter James Watts
Life of this patent
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Abstract
A composition for intranasal delivery of a drug comprising: includes: (i) the drug; and (ii) a non-aqueous vehicle containing (a) propylene glycol and at least one additional solvent selected from N-methylpyrrolidone, propylene carbonate, dimethyl sulfoxide and at least one propylene glycol fatty acid ester; (b) from about 40 to 100% by volume of N-methylpyrrolidone; or (c) from about 40 to 100% by volume of dimethyl sulfoxide (DMSO).
Claims27
A non-aqueous liquid composition for intranasal delivery of a benzodiazepine drug consisting essentially of:
- (i) the drug;
- and
- (ii) a non-aqueous vehicle consisting essentially of about 30 to 85% v/v propylene glycol and 15 to 70% v/v propylene carbonate,
- wherein the non-aqueous liquid composition is suitable for delivery in a form of drops or a spray.
A method for intranasal delivery of a benzodiazepine drug to a patient in need thereof, the method comprising providing a non-aqueous liquid composition consisting essentially of a benzodiazepine drug and a non-aqueous vehicle for the drug, the vehicle consisting essentially of about 30 to 85% v/v propylene glycol and 15 to 70% v/v propylene carbonate;
- and intranasally administering the non-aqueous liquid composition to the patient in a form of drops or a spray.
A method for treating anxiety or epilepsy or for inducing sedation or anticonvulsant actions, the method comprising providing a non-aqueous liquid composition consisting essentially of a benzodiazepine drug selected from diazepam, lorazepam, clonazepam and midazolam in an amount effective for treating anxiety or epilepsy or for inducing sedation or anticonvulsant actions, and a non-aqueous vehicle consisting essentially of about 30 to 85% v/v propylene glycol and 15 to 70% v/v propylene carbonate;
- and intranasally administering the non-aqueous liquid composition to the patient in a form of drops or a spray.
Dependencies are inferred from the claim text.