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US 8,946,206 B2Granted
Methods for improving cognitive function
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsCraig C. Garner, H. Craig Heller, Damien Colas, Daniel Z. Wetmore
Life of this patent
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Abstract
Provided herein are methods, drug formulations, and dosing regimens for improving cognitive function in a normal or cognitively impaired subject. For instance, methods provided herein comprise administering a GABAA receptor antagonist so that peak concentration of the GABAA receptor antagonist occurs when the subject is asleep.
Claims16
A method for improving a cognitive function in a human subject with Down syndrome comprising
- administering to the subject a therapeutically effective dose of pentylenetetrazole in a delayed release formulation or a sustained release formulation so that peak concentration of the pentylenetetrazole in the subject occurs when the subject is asleep, wherein the administering is effective to achieve improvement in the cognitive function.
A method for improving a cognitive function in a human subject with Down syndrome comprising
- administering to the human subject pentylenetetrazole at a dose of 0.01 to 15 mg/kg body weight of the subject, wherein pentylenetetrazole is administered such that the peak concentration of pentylenetetrazole in the human subject occurs when the human subject sleeps,
- whereby said administering is effective to achieve improvement in the cognitive function as measured using a protocol for assessing the cognitive function.
Dependencies are inferred from the claim text.