Substituted porphyrins
AssigneesAeolus Sciences, Inc., National Jewish Health, Duke University
InventorsJames D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Abstract
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Claims9
A method of treating cardiomyopathy mediated by oxidative stress in a patient in need thereof, said method comprising administering to said patient an effective amount of a compound of formula
- or pharmaceutically accept salt thereof,
- wherein
- R1 and R3 are the same and are:
- R2 and R4 are the same and are:
- Y is halogen or —CO2X,
- each X is the same or different and is an alkyl;
- and
- each R5 is the same or different and is H or alkyl.
Dependencies are inferred from the claim text.