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US 8,946,199 B2Granted
Co-administration of steroids and Zoledronic acid to prevent and treat side effects from Zoledronic acid infusion
OwnerKetan Desaiinventor
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OwnerKetan Desaiinventor
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Zoledronic Acid is used for treatment of hypercalcemia of malignancy, for the treatment of bone metastasis associated with malignancies such as prostate and breast cancer, for the prevention of and treatment of osteoporosis and for the treatment of Paget's disease. Administration of Zoledronic Acid is complicated by what is described as “post-dosing syndrome” (PDS) and osteonecrosis of the jaw (ONJ). Inflammation may be the cause of these side effects, which could be decreased by the co-administration of steroids. This application is a method of use patent for the co-administration of steroids (oral, IV, IM, rectal, or by inhalation) with Zoledronic Acid and a composition of matter patent for mixing Methyl Prednisolone with Zoledronic Acid for infusion.
A method of treating a patient suffering from a disorder ameliorated by treatment with zoledronic acid, while minimizing the side effects associated with the administration of zoledronic acid, comprising administering zoledronic acid and a steroid intravenously, wherein the zoledronic acid and the steroid are administered in a single infusion, wherein the steroid is prednisolone,
A method treating a patient suffering from a disorder ameliorated by treatment with zoledronic acid, while minimizing the side effects associated with the administration of zoledronic acid, comprising administering zoledronic acid intravenously, and administering prednisolone about half an hour after the zoledronic acid infusion,
A method treating a patient suffering from a disorder ameliorated by treatment with zoledronic acid, while minimizing the side effects associated with the administration of zoledronic acid, comprising administering zoledronic acid intravenously, and administering prednisolone subcutaneously, intramuscularly, by inhalation, or by a rectal suppository
A method of treating a patient suffering from osteoporosis, comprising administering zoledronic acid and prednisolone intravenously in a single infusion.
Dependencies are inferred from the claim text.