Transplants
AssigneeHibernation Therapeutics, A KF LLC
InventorGeoffrey Phillip Dobson
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Abstract
The present invention relates to a method of reducing injury to cells, a tissue or organ to be explanted from a body and upon implantation into a body by administering a composition to the cell, tissue or organ, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. The invention also provides a composition for reducing injury to vasculature ex vivo including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent.
Claims17
A method of reducing the patency failure rate of a transplanted vasculature graft, the method comprising:
- Prior to transplantation, administering ex vivo to the graft a composition comprising
- i) a potassium channel opener or agonist and/or an adenosine receptor agonist;
- and
- ii) an anti-arrhythmic agent
- wherein the patency failure rate post operatively of the transplanted vasculature graft is reduced.
Dependencies are inferred from the claim text.