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US 8,946,186 B2Granted
QSOX1 as an anti-neoplastic drug target
AssigneeArizona Board of Regents, A Body Corporate of the State of Arizona Acting for and On Behalf of Arizona State University
InventorsDouglas Lake, Benjamin Katchman
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Abstract
The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.
Claims28
An isolated nucleic acid encoding a shRNA molecule comprising a nucleic acid of 5′-CCGGACAATGAAGAAGCCTTT-3′ (SEQ ID NO:
- 21) and its complement, or an RNA equivalent thereof;
- or a nucleic acid of 5′-TCTAGCCACAACAGGGTCAAT-3′ (SEQ ID NO:
- 22) and its complement, or an RNA equivalent thereof.
An isolated nucleic acid encoding an shRNA molecule comprising a nucleic acid that encodes the complement of a nucleic acid of the general formula:
- (SEQ ID NO:
- 23)
- CCGG-X1-CTCGAGAAACTTTCTCACCACATTGGCTTTTTG-3′
- or an RNA equivalent thereof;
- wherein X1 is a nucleic acid sequence selected from the group consisting of
- (SEQ ID NO:
- 11)
- 5′-A(T/U)C(T/U)ACA(T/U)GGC(T/U)GACC(T/U)GGAA-3′
- (SEQ ID NO:
- 12)
- 5′-AGGAAAGAGGG(T/U)GCCG(T/U)(T/U)C(T/U)(T/U)-3′,
- (SEQ ID NO:
- 13)
- 5′-GCCAA(T/U)G(T/U)GG(T/U)GAGAAAG(T/U)(T/U)(T/U)-
- 3′,
- (SEQ ID NO:
- 14)
- 5′-GCCAAGAAGG(T/U)GAAC(T/U)GGA(T/U)(T/U)-3′.
- (SEQ ID NO:
- 15)
- 5′-CCGGACAA(T/U)GAAGAAGCC(T/U)(T/U)(T/U)-3′
- (SEQ ID NO:
- 16)
- 5′-(T/U)C(T/U)AGCCACAACAGGG(T/U)CAA(T/U)-3′
- (SEQ ID NO:
- 17)
- 5′-ATCTACATGGCTGACCTGGAA-3′,
- (SEQ ID NO:
- 18)
- 5′-AGGAAAGAGGGTGCCGTTCTT-3′,
- (SEQ ID NO:
- 19)
- 5′-GCCAATGTGGTGAGAAAGTTT-3′,
- (SEQ ID NO:
- 20)
- 5′-GCCAAGAAGGTGAACTGGATT-3′,
- (SEQ ID NO:
- 21)
- 5′-CCGGACAATGAAGAAGCCTTT-3′;
- and
- (SEQ ID NO:
- 22)
- 5′-TCTAGCCACAACAGGGTCAAT-3′.
40 more elements
Dependencies are inferred from the claim text.