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US 8,946,179 B2Granted
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
AssigneeRegulus Therapeutics Inc.
InventorsC. Frank Bennett, Susan M. Freier, Richard H. Griffey
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Abstract
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
Claims21
A method of treating or preventing a disease or disorder associated with a microRNA comprising:
- contacting an animal having or predisposed to the disease or disorder with a therapeutically effective amount of compound comprising an oligomeric compound consisting of 15 to 30 monomeric subunits;
- wherein the oligomeric compound is at least 90% complementary to the microRNA, and at least one monomeric subunit is a modified nucleoside;
- thereby treating or preventing the disease or disorder;
- wherein the disease or disorder is selected from cancer, diabetic retinopathy, cardiovascular disease, rheumatoid arthritis, and psoriasis, and wherein the oligomeric compound inhibits or reduces one or more markers of angiogenesis selected from integrin beta3 expression, endoglin expression, TEM5 expression, MMP14 expression, MMP activity, and endothelial tube formation.
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A method of inhibiting angiogenesis comprising:
- contacting a cell with a compound comprising an oligomeric compound consisting of 15 to 30 monomeric subunits;
- wherein the oligomeric compound is at least 90% complementary to a microRNA;
- and
- wherein at least one monomeric subunit is a modified nucleoside or a nucleoside mimetic;
- wherein the oligomeric compound inhibits or reduces one or more markers of angiogenesis selected from integrin beta3 expression, endoglin expression, TEM5 expression, MMP14 expression, MMP activity, and endothelial tube formation;
- thereby inhibiting angiogenesis.
3 more elements
Dependencies are inferred from the claim text.