Cancer cell death inducing agent having effects of potentiating anticancer drug against anticancer-drug-resistant cancer
AssigneeMomotaro-Gene Inc.
InventorsHiromi Kumon, Yasutomo Nasu, Masami Watanabe, Yuji Kashiwakura, Kensuke Kawasaki
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Abstract
The present invention provides a drug capable of causing cancer cells to restore anticancer drug sensitivity in cases in which cancer has acquired resistance to an anticancer drug and inducing cell death in cancer cells. The present invention specifically provides a cancer cell death inducing agent comprising REIC/Dkk-3 DNA as an active ingredient and having effects of potentiating an anticancer drug for cancer cells having anticancer drug resistance.
Claims3
A method for causing a mammary cancer cell having resistance against doxorubicin to restore anticancer drug sensitivity and then inducing cancer cell death, comprising administering the following REIC/Dkk-3 DNA or a vector containing the DNA to a mammary cancer cell having resistance to doxorubicin:
- (a) a DNA consisting of the nucleotide sequence shown in SEQ ID NO:1,
- wherein the anticancer drug resistance is caused by upregulation of P-glycoprotein.
Dependencies are inferred from the claim text.