Method of treatment using stable liquid formulation of G-CSF
Assigneeratiopharm GmbH
InventorsWalter Hinderer, Heinz Lubenau
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Abstract
Provided are pharmaceutical liquid formulations of G-CSF, which are stable over a long time period and substantially free of excipients, as well as ready-to-use syringes containing such formulations and corresponding kits.
Claims12
A method for the treatment of cancer, severe chronic neutropenia (SCN), HIV infection, a damage of the central nervous system, adverse side effects owing to cytotoxic chemotherapy, or for the accompanying therapy of diseases, wherein a mobilization of peripheral blood precursor cells is required, the method comprising administering a therapeutically effective amount of a medicament to a patient in need thereof, wherein the medicament comprises an aqueous liquid formulation of G-CSF, the aqueous liquid formulation of G-CSF comprising G-CSF, sorbitol at a concentration of 5% w/v, polysorbate at a concentration of 0.05 to 0.06 mg/ml, and acetate at a concentration of 10 mM as a buffer substance at a pH value of 4.15 to 4.3.
Dependencies are inferred from the claim text.