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US 8,946,160 B2Granted
Nitric oxide amino acid esters for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation
AssigneeOral Delivery Technology Ltd.
InventorMichael Farber
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Abstract
Use of nitric oxide amino acid esters for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation, such as peripheral vascular disease. The nitric oxide amino acid esters may be co-administered with an antimicrobial in topical or transdermal compositions for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation.
Claims3
A topical composition comprising:
- an effective amount of a compound selected from the group consisting of (2-nitrooxy)-2-ethylamino-3-methylbutanoate
- valine butylene glycol nitrate
- 2′-nitrooxyethyl 2-amino-pentanoate
- and 4′-nitrooxybutyl 2-amino-pentanoate
- or any pharmaceutically acceptable salts thereof;
- and
- at least one topical antimicrobial,
- in association with a pharmaceutically acceptable topical carrier.
5 more elements
Dependencies are inferred from the claim text.