Long-acting polypeptides and methods of producing and administering same
AssigneeOPKO Biologics Ltd.
InventorsFuad Fares, Udi Eyal Fima
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Abstract
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
Claims32
A method of reducing the dosing frequency of a growth hormone in a subject, comprising administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of a modified growth hormone with one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus of said growth hormone and two chorionic gonadotrophin CTPs attached to the carboxy terminus of said growth hormone, wherein said modified growth hormone optionally comprises a signal peptide attached to the amino terminus of said one CTP, and wherein the dosing frequency of said modified growth hormone is thereby reduced as compared to the dosing frequency of a corresponding unmodified growth hormone in a subject.
A method of improving the area under the curve (AUC) of a growth hormone in a subject, comprising administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of a modified growth hormone with one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus of said growth hormone and two chorionic gonadotrophin CTPs attached to the carboxy terminus of said growth hormone, wherein said modified growth hormone optionally comprises a signal peptide attached to the amino terminus of said one CTP, and wherein the AUC of said modified growth hormone is thereby improved as compared to the AUC of a corresponding unmodified growth hormone in a subject.
Dependencies are inferred from the claim text.