Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
AssigneeMedical Diagnostic Laboratories, LLC
InventorsGrant Gallagher, Raymond Yu, Jonathan Brazaitis
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Abstract
The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX1X2X3W, where W is tryptophan, and X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining two of X1, X2 or X3 cannot be W. The present invention relates a composition containing the novel polypeptides, and use of same in treating IL-23 associated human diseases including, for example, inflammatory bowel diseases, psoriasis and Crohn's disease.
Claims17
An isolated polypeptide of 9-18 amino acids in length, said isolated polypeptide comprises a core structure having an amino acid sequence of WX1X2X3W, wherein X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining X1, X2 or X3 cannot be W, and
- wherein said isolated polypeptide is capable of inhibiting the binding of IL-23 to IL-23 receptor and the IL-23-mediated signaling.
An isolated polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 5, SEQ ID NO:
- 19, SEQ ID NO:
- 25, SEQ ID NO:
- 70, and SEQ ID NO:
- 93, wherein said isolated polypeptide is capable of inhibiting the binding of IL-23 to IL-23 receptor and the IL-23-mediated signaling.
An isolated polypeptide of 9-18 amino acids in length, said isolated polypeptide comprises a core structure having an amino acid sequence of WX1X2X3W, wherein W is tryptophan, X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining X1, X2 or X3 cannot be W, and wherein said isolated polypeptide binds to soluble recombinant human IL-23R and inhibits binding between IL-23 and its corresponding receptor thereof.
Dependencies are inferred from the claim text.