Use of exendin and analogs thereof to delay or prevent cardiac remodeling
AssigneesAmylin Pharmaceuticals, Inc., AstraZeneca Pharmaceuticals LP
InventorsChristen Anderson, Que Liu
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Abstract
The present invention relates generally to the novel use of cardioprotective incretin compounds (CICs) such as GLP-1 and exendin and agonists thereof, including analogs and derivatives to prevent, delay, attenuate, or ameliorate cardiac remodeling. The present invention relates to methods for using CICs for the treatment of conditions associated with cardiac remodeling. The present invention further relates to methods for using CICs for the reduction of the risk or severity of congestive heart failure.
Claims24
A method for attenuating or delaying cardiac remodeling, said method comprising:
- administering to a subject in need thereof an amount of a cardioprotective incretin compound (CIC) effective to prevent a deleterious effect on or improve at least one cardiac parameter in said subject, whereby cardiac remodeling is attenuated or delayed, wherein said subject has experienced, or is experiencing, cardiac remodeling following a myocardial insult;
- and wherein said CIC is exendin-3, exendin-4, an exendin-3 analog with GLP-1 receptor agonist activity or an exendin-4 analog with GLP-1 receptor agonist activity, and wherein said CIC is administered after the myocardial insult.
A method for reducing atrial or ventricular remodeling, said method comprising:
- administering to a subject in need thereof an amount of a cardioprotective incretin compound (CIC) effective to reduce atrial or ventricular remodeling, wherein said subject has experienced, or is experiencing, atrial or ventricular remodeling following a myocardial insult, and wherein said CIC is exendin-3, exendin-4, an exendin-3 analog with GLP-1 receptor agonist activity or an exendin-4 analog with GLP-1 receptor agonist activity, and wherein said CIC is administered after the myocardial insult.
Dependencies are inferred from the claim text.