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US 8,946,148 B2Granted
Modified insulin polypeptides and their uses
AssigneeAmbrx, Inc.
InventorsZhenwei Miao, Denise Krawitz, Vadim Kraynov, Feng Tian, Bee-Cheng Sim, Lillian Skidmore, Anna-Maria A. Hays Putnam, Nick Knudsen, Michael Deguzman
Life of this patent
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Abstract
Modified insulin polypeptides and their uses thereof are provided.
Claims3
An insulin polypeptide comprising a para-acetyl-phenylalanine
- substituted at one of the following positions:
- in the B chain at L17, F25 (SEQ ID NO:
- 4);
- and wherein the para-acetyl-phenylalanine is conjugated to one or more lipid molecule(s).
1 more element
Dependencies are inferred from the claim text.