Personal glucose meters for detection and quantification of a broad range of analytes

A lateral flow device, comprising:

• a first region of a solid support to which is attached a first nucleic acid molecule that specifically binds to a target agent but not significantly to other agents;
• an enzyme attached to a second nucleic acid molecule, wherein the second nucleic acid molecule is complementary to a portion of the first nucleic acid molecule, thereby generating an enzyme-conjugate, wherein the enzyme-conjugate is hybridized to the first nucleic acid molecule, wherein the enzyme catalyzes the conversion of a substance into glucose, and wherein in the presence of the target agent the enzyme-conjugate is released and separated from the first nucleic acid molecule, and the enzyme converts the substance into glucose;
• and
• the substance that is converted into glucose by the enzyme, wherein the substance is soluble and attached to a second region of the solid support.

A lateral flow device, comprising:

• a first region of a solid support to which is attached a nucleic acid molecule that specifically binds to a target agent but not significantly to other agents;
• an enzyme attached to an analogue of the target agent, thereby generating an enzyme-analog conjugate, wherein the enzyme-analog conjugate is bound to the nucleic acid molecule, wherein the enzyme catalyzes the conversion of a substance into glucose, and wherein in the presence of the target agent the enzyme-analog conjugate is released and separated from the nucleic acid molecule, and the enzyme converts the substance into glucose;
• and
• the substance that is converted into glucose by the enzyme, wherein the substance is soluble and attached to a second region of the solid support.

A lateral flow device, comprising:

• a first solid support to which is attached a nucleic acid molecule that specifically binds to a target agent but not significantly to other agents;
• an enzyme attached to an analogue of the target agent, thereby generating an enzyme-analog conjugate, wherein the enzyme-analog conjugate is bound to the nucleic acid molecule, wherein the enzyme catalyzes the conversion of a substance into glucose, and wherein in the presence of the target agent the enzyme-conjugate is released and separated from the nucleic acid molecule, and the enzyme converts the substance into glucose;
• and
• the substance that is converted into glucose by the enzyme, wherein the substance is soluble and attached to a second solid support.