Stabilization of bio-sensors for in vivo applications
AssigneeEyeSense AG
InventorsPeter Herbrechtsmeier, Achim Müller, Monika Knuth, Katharina Nikolaus
Life of this patent
Estimating the term…
Abstract
The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
Claims7
A method for maintaining the function of concanavalin A in a biochemical sensor comprising contacting the concanavalin A with a cell lysate fraction comprising precanavalin, wherein the cell lysate fraction comprising precanavalin is produced by a method comprising the steps:
- (a) producing the cell lysate from cells;
- and
- (b) separating the concanavalin A from the cell lysate, thereby obtaining the cell lysate fraction comprising precanavalin for maintaining the function of the concanavalin A, and wherein the cell lysate fraction comprising precanavalin as compared to known stabilizers improves the stability of the concanavalin A.
A biochemical sensor comprising concanavalin A that binds with high affinity to a substance that is to be detected and a cell lysate fraction comprising precanavalin, wherein the cell lysate fraction comprising precanavalin is in contact with concanavalin A to maintain the function of concanavalin A.
Dependencies are inferred from the claim text.