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US 8,945,927 B2Granted
Polymers for delivering molecules of interest
AssigneesUniversite De Strasbourg, Centre National De La Recherche Scientifique
InventorsGuy Zuber, Benoit Frisch, Gaelle Creusat, Jean-Sebastien Thomann
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Abstract
The present invention relates to a new class of cationic polymers that self-assemble with a pH-sensitive dissolution switch, and their uses to deliver molecules of interest to a cell. The present invention also relates to compositions comprising said cationic polymers non-covalently associated with a molecule of interest, in particular with a siRNA.
Claims26
A polyethylenimine having multiple amine functions modified or substituted by a radical X, wherein
- X is C(═Z)—R1
- wherein
- Z is S or O;
- and
- R1 is selected from the group consisting of:
- and optionally a combination thereof
- wherein r is an integer from 0 to 2, R is independently selected from the group consisting of H, OH, OCH3, NH2, O(CH2CH2O)mH, and O(CH2CH2O)mCH3 with m being an integer between 1 and 500;
- wherein the polyethylenimine has from 10 to 2000 ethylenimine units.
5 more elements
Dependencies are inferred from the claim text.