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US 8,945,910 B2Granted
Method and apparatus for an improved sample capture device
AssigneeSanofi-Aventis Deutschland GmbH
InventorsTravis Marsot, Paul Lum, Don Alden, James Ross, Ron L. Bardell, Bernhard Hans Weigl
Life of this patent
Estimating the term…
Abstract
A body fluid sampling device is provided. A mesh (120) may be used to guide blood or fluid to travel directly form the wound to an analyte detecting port on the cartridge (121). Thus the volume of blood or body fluid produced at the wound site irregardless of its droplet geometry can be reliable and substantially completely transported to the analyte detecting member (150) for measurement.
Claims24
A body fluid sampling device comprising:
- an indexable cartridge;
- a plurality of penetrating members positioned in the cartridge, the penetrating members movable to extend radially outward from the cartridge to penetrate tissue;
- a plurality of analyte detecting members positioned in the cartridge, wherein at least one of the analyte detecting members positioned on the cartridge to receive body fluid from a wound in the tissue created by a penetrating member when the cartridge is in an operative position;
- and
- a structure to draw fluid generated by the tissue towards one of the analyte detecting members;
- and
- wherein an initial concentration (mm) of an analyte detecting member is:
- [HO2]=fAqSO2Aq+fSiSO2 Si,
- the effective partition coefficient is
- H
- 02
- =
- f
- Aq
- +
- S
- 02
-
- Si
- S
- 02
-
- Aq
- ,
- and the diffusion coefficient
- DO2=fAgD02 Aq+fPoly(1−fSi)DO2 Poly+fSiDO2 Si
- where fsi is the volume fraction of the emulsion that is hydrophobic phase, fAq and fPoly are the volume fractions of the hydrophilic phase that are aqueous and polymer, respectively;
- the diffusion coefficients of oxygen in water, hydrogel polymer, and hydrophobic phase are D02Aq, D02 Poly and Do2si;
- and finally the solubilities of oxygen in water and hydrophobic phase at initial conditions are SO2 Aq and SO2 Si in mM units.
26 more elements
A body fluid sampling device comprising:
- a housing;
- a cartridge positionable and removable from the housing;
- a plurality of penetrating members positioned in the cartridge and operatively couplable to a penetrating member driver;
- a plurality of analyte detecting members positioned in the cartridge, wherein at least one of the analyte detecting members positioned on the cartridge to receive body fluid from a wound in the tissue created by a penetrating member when the cartridge is in an operative position, the plurality of penetrating members and plurality of analyte detecting members positioned in the cartridge;
- and
- a movement structure that moves penetrating members in the cartridge into positions for launching of penetrating members to create a tissue penetration event;
- and
- wherein an initial concentration (mm) of an analyte detecting member is:
- [HO2]=fAqSO2Aq+fSiSO2 Si,
- the effective partition coefficient is
- H
- 02
- =
- f
- Aq
- +
- S
- 02
-
- Si
- S
- 02
-
- Aq
- ,
- and the diffusion coefficient
- DO2=fAgD02 Aq+fPoly(1−fSi)DO2 Poly+fSiDO2 Si
- where fSi is the volume fraction of the emulsion that is hydrophobic phase, fAq and fPoly are the volume fractions of the hydrophilic phase that are aqueous and polymer, respectively;
- the diffusion coefficients of oxygen in water, hydrogel polymer, and hydrophobic phase are D02Aq, D02 Poly and Do2si;
- and finally, the solubilities of oxygen in water and hydrophobic phase at initial conditions are SO2 Aq and SO2 Si in mM units.
27 more elements
Dependencies are inferred from the claim text.