Materials and methods for conjugating a water soluble fatty acid derivative to a protein
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsJuergen Siekmann, Richard Sheinecker, Hanspeter Rottensteiner, Peter Turecek
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Abstract
The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water soluble fatty acid derivative under conditions that allow conjugation.
Claims37
A water soluble fatty acid derivative comprising a fatty acid or fatty acid ester attached to a water soluble linker, said fatty acid derivative stably attached to a therapeutic protein, wherein the water soluble linker comprises a water soluble polymer, at least one first functional group attached to the therapeutic protein, wherein the first functional group is an aminooxy group, and a second functional group attached to the fatty acid or fatty acid ester, wherein the second functional group is an aminooxy group.
Dependencies are inferred from the claim text.