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US 8,945,893 B2Granted
Conversion of prenyl derivatives to isoprene
AssigneesDanisco US Inc., The Goodyear Tire & Rubber Company
InventorsJoseph C. McAuliffe, Samira Rathnayake, Karl J. Sanford
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Abstract
The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl derivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene or prenyl derivatives produced there from.
Claims11
A method of producing isoprene, the method comprising
- (a) culturing host cells comprising one or more nucleic acid(s) encoding one or more phosphatases of enzyme class 3.6.1, 3.1.7 or 3.1.3 under suitable culture conditions for the production of a prenyl derivative of Formula (I):
- wherein R1 is hydrogen or —C(O)R2;
- and
- R2 is C1-C5 linear or branched alkyl;
- (b) recovering said prenyl derivative;
- and
- (c) dehydrating or decarboxylating said prenyl derivative to produce isoprene.
4 more elements
Dependencies are inferred from the claim text.