Method for producing high amount of glycolic acid by fermentation
AssigneeMetabolic Explorer
InventorsWanda Dischert, Philippe Soucaille
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Abstract
The present invention relates to an improved method for the bioconversion of a fermentable carbon source to glycolic acid by a recombinant microorganism bearing new genetic modifications such as ΔldhA, ΔmgsA, ΔarcA, and ΔlldP, ΔglcA, ΔyjcG and combination of them allowing a production with higher yield, titer and productivity.
Claims19
A method for the fermentative production of glycolic acid, its derivatives or precursors, by culturing a modified microorganism, in an appropriate culture medium comprising a source of carbon, and recovery of glycolic acid from the culture medium,
- wherein said modified microorganism is a gram negative bacteria genetically modified for producing glycolic acid, that further comprises attenuation of the genes ldhA and mgsA.
A gram negative bacteria microorganism genetically modified for producing glycolic acid, that further comprises attenuation of the genes ldhA and mgsA.
Dependencies are inferred from the claim text.