US 8,945,874 B2 · Polynucleotides encoding NOTCH1 receptor antibodies

Abstract

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

Claims22

Dependent claims

An isolated polynucleotide encoding an antibody that specifically binds human NOTCH1, wherein the antibody comprises:

(a) a heavy chain CDR1 comprising RGYWIE (SEQ ID NO:15);
a heavy chain CDR2 comprising QILPGTGRTNYNEKFKG (SEQ ID NO:16);
and a heavy chain CDR3 comprising FDGNYGYYAMDY (SEQ ID NO:17);
and
(b) a light chain CDR1 comprising RSSTGAVTTSNYAN (SEQ ID NO:18);
a light chain CDR2 comprising GTNNRAP (SEQ ID NO:19);
and a light chain CDR3 comprising ALWYSNHWVFGGGTKL (SEQ ID NO:20).

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/801,613Filed 13 Mar 2013 · continuation

Priority

8 Jul 2008

Published

US 2014/0011271 A19 Jan 2014

Granted

3 Feb 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification40 codes

C07K 16/22
Against material from animals or humans: against growth factors ; against growth regulators
A61K 31/337
Having oxygen as the only ring hetero atom, e.g. fungichromin: having four-membered rings, e.g. taxol
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens

Family

Application61/079,095Us provisional application · filed 8 Jul 2008

Application61/112,699Us provisional application · filed 7 Nov 2008

Application61/112,701Us provisional application · filed 7 Nov 2008

PCT/US2009/003995Parent of this continuation · filed 8 Jul 2009

US 2014/0011271 A1Pre-grant publication · published 9 Jan 2014

Application13/003,013Parent of this continuation

US 8,435,513 B2Parent of this continuation

US 2011/0311552 A1Published application

US 8,945,874 B2This patent

From the US filing history. Foreign family members aren’t listed.

Polynucleotides encoding NOTCH1 receptor antibodies

Life of this patent

Polynucleotides encoding NOTCH1 receptor antibodies

Life of this patent

Abstract

Claims22