Method for biostable inclusion of a biobeneficial agent on an outermost surface of an implantable medical device

A method, comprising:

• providing an implantable medical device comprising a device body;
• optionally disposing a primer layer over an exposed surface of the device body;
• disposing a drug reservoir layer over an exposed surface of the device body or, if opted for, over the primer layer, wherein:
• the drug reservoir layer comprises:
• a first polymer that includes at least one constitutional unit having a carbon-hydrogen bond capable of radical formation,
• a UV and/or visible light sensitive therapeutic agent;
• and
• optionally, a UV or visible light blocker that absorbs UV or visible radiation at the wavelength(s) to which the therapeutic agent is sensitive;
• optionally disposing a topcoat layer over the drug reservoir layer wherein the topcoat layer comprises a second polymer, which may be the same as or different than the first polymer, wherein
• the second polymer has at least one constitutional unit having a carbon-hydrogen bond capable of radical formation, wherein
• if the topcoat layer is opted for it optionally further comprises a UV or visible light blocker that absorbs UV or visible radiation at the wavelength(s) to which the therapeutic agent is sensitive;
• disposing a UV or visible light active biobeneficial agent over the drug reservoir layer or, if opted for, over the topcoat layer;
• and,
• curing the device with UV or visible radiation wherein:
• a covalent bond is formed between the UV light active biobeneficial agent and the first polymer or, if a top coat is opted for, the second polymer,
• wherein the UV or visible light active biobeneficial agent comprises a biobeneficial agent to which a UV or visible light radical-forming entity has been covalently bonded.